Provisional Patent Application Filed for AI-Guided Bioelectric Enhanced Regenerative Dentistry System
Huntington Beach, California — Lionheart Health, Inc. today announced the unveiling of DentaCell™, a next-generation regenerative dentistry platform that combines personalized bioelectric stimulation, regenerative biologics, artificial intelligence, advanced digital dentistry, and precision treatment planning to support regeneration of periodontal tissues, gingiva, alveolar bone, oral soft tissues, and improved long-term oral health.
The company also announced the filing of a provisional patent application covering multiple embodiments of the DentaCell™ platform, including AI-guided treatment planning, personalized bioelectric stimulation protocols, bioelectric enhancement of regenerative biologics, intelligent treatment monitoring, and custom 3D-printed therapeutic delivery systems.
“Dentistry is entering an era where regeneration can become personalized. Rather than relying on a single material or biologic, DentaCell™ is being designed as an intelligent platform that integrates bioelectric medicine, regenerative biologics, AI, digital imaging, and personalized treatment delivery to help optimize healing for each individual patient.”
— Howard J. Leonhardt
Executive Chairman & Co-CEO
Lionheart Health, Inc.
A Personalized Regenerative Dentistry Platform
DentaCell™ is being developed as a comprehensive regenerative platform intended to combine:
- Personalized bioelectric stimulation
- AI-driven treatment planning
- Bioelectric-enhanced regenerative biologics
- Platelet-Rich Fibrin (PRF)
- Injectable PRF
- BioPRF™
- Stromal Vascular Fraction (SVF)
- Bone Marrow Concentrate (BMAC)
- Stem cell homing technologies
- Digital treatment planning
- 3D printed patient-specific treatment appliances
- Remote treatment monitoring
Unlike conventional regenerative dental products that primarily utilize scaffold materials or isolated biologics, DentaCell™ is intended to integrate multiple regenerative technologies into one personalized therapeutic system.
Artificial Intelligence Personalization
The DentaCell™ software platform is intended to analyze:
- CBCT scans
- Intraoral digital scans
- Digital impressions
- Bone quality
- Periodontal pocket depth
- Gingival recession
- Tooth stability
- Occlusion
- Bite-force measurements
- Oral photographs
- Healing progress
- Medical history
- Age
- Inflammatory biomarkers
- Salivary biomarkers
- Previous treatment response
Using these inputs, the AI platform is intended to recommend individualized bioelectric treatment parameters and regenerative biologic combinations tailored to each patient’s clinical presentation.
Bioelectric Protein Expression Programming
A core component of DentaCell™ is Lionheart Health’s ongoing research into proprietary bioelectric stimulation waveforms designed to influence cellular signaling pathways associated with tissue repair and regeneration. These investigational protocols are being explored for their potential to encourage expression of proteins involved in healing.
Research targets include:
Stem Cell Recruitment
- SDF-1 (CXCL12)
- PDGF
- CXCR4 signaling
Blood Vessel Formation
- VEGF
- eNOS
- HIF-1α
Bone Regeneration
- BMP-9
- RUNX2
- Osteocalcin
- Alkaline Phosphatase
Bone Remodeling
- Osteoprotegerin (OPG)
- Balanced RANKL/OPG signaling
Healthy Tissue Remodeling
- Tropoelastin
- COL17A1
- Collagen remodeling pathways
Healthy Aging Biology
- Klotho
- Sestrins
- Sirtuins
- Apelin
Bioelectric Enhanced Regenerative Biologics
DentaCell™ is also being developed to combine bioelectric stimulation with regenerative biologic therapies before, during, and following treatment.
Potential biologic combinations under investigation include:
- Platelet-Rich Fibrin (PRF)
- Injectable PRF
- BioPRF™
- Stromal Vascular Fraction
- Bone Marrow Concentrate
- Exosomes
- Secretome products
- Placental-derived biologics
- Peptide therapies where permitted by applicable regulations
The objective is to support cellular recruitment, vascularization, tissue integration, and healing.
Intelligent 3D Printed Treatment Appliances
Future embodiments described in the provisional patent application include custom patient-specific oral appliances manufactured from digital scans.
Potential features include:
- Precision electrode positioning
- Integrated light therapy channels
- Bioelectric treatment delivery
- Medication reservoirs
- Pressure optimization
- Bite-force sensors
- Treatment verification sensors
- Wireless treatment monitoring
- Cloud-connected treatment updates
Clinical Applications Under Development
DentaCell™ is being designed for future investigation across numerous regenerative dentistry applications, including:
- Periodontal regeneration
- Gingival tissue restoration
- Alveolar bone regeneration
- Bone graft enhancement
- Dental implant site preparation
- Implant integration support
- Tooth extraction healing
- Socket preservation
- Guided tissue regeneration
- Oral wound healing
- Cosmetic soft tissue enhancement
- Peri-implant tissue health
- Oral surgery recovery
- Jaw bone preservation
- TMJ supportive therapies
Future Platform Expansion
Future embodiments described in the provisional patent application also include potential integration with:
- Near-infrared photobiomodulation
- Red light therapy
- Pulsed electromagnetic field therapy (PEMF)
- Acoustic stimulation
- Mechanical micro-vibration
- Salivary biomarker analysis
- Cloud-based AI optimization
- Remote physician monitoring
- Longitudinal digital treatment tracking
Research and Development
DentaCell™ is currently in research and development. Lionheart Health intends to pursue laboratory studies, preclinical validation, and future clinical investigations to evaluate safety and performance. Any references to modulation of protein expression, regenerative activity, or anticipated clinical applications describe investigational objectives and should not be interpreted as established clinical outcomes.
About Lionheart Health
Lionheart Health, Inc. is developing bioelectric medicine technologies intended to advance regenerative medicine, longevity science, aesthetics, cardiovascular health, musculoskeletal medicine, neurological wellness, sexual health, vision, hearing, oral regeneration, and other emerging applications. The company’s technology platform combines precision bioelectric stimulation, regenerative biologics, artificial intelligence, and personalized treatment delivery across more than 25 investigational therapeutic programs.
Media Contact
Howard J. Leonhardt
Executive Chairman & Co-CEO
Lionheart Health, Inc.
www.LionheartHealthStim.com
www.LionheartLongevity.com
Forward-Looking Statements
This press release contains forward-looking statements regarding technologies under development. DentaCell™ is an investigational platform www.DentaCellAccelerator.com and has not received regulatory clearance or approval. Statements regarding anticipated capabilities, future applications, or potential clinical benefits reflect research and development objectives and should not be interpreted as evidence of established safety or effectiveness.