KlothoYears

The Klotho Protein: Your Blueprint for Longevity

Is Your Klotho Level Optimized for a Longer, Healthier Life?

Optimizing your Klotho level may be a key factor in promoting a longer, healthier life. Named after the Greek goddess who spins the thread of life, Klotho is a protein with powerful anti-aging properties. Research suggests that maintaining a healthy Klotho level can help protect your body and brain from age-related decline.

What is Klotho?

Studies have shown connections between Klotho, healthy aging, and disease resistance.

Klotho is a protein found throughout the body, including in the kidneys, liver, brain, and blood. It plays a crucial role in many essential bodily functions that contribute to overall health and longevity. Although it is not widely known outside of research and longevity circles, Klotho is being studied as a key indicator of age-related health changes and a potential target for improving overall health and treating various diseases. This vital protein gets its name from Clotho, a Greek goddess and one of the three fates, who, according to myth, spins the thread of life. This connection highlights Klotho’s vital link to longevity.

Greek Gods and Goddesses – Clotho spins the web of life

The Connection Between Klotho and Healthy Aging

A growing body of scientific evidence links higher Klotho levels with a reduced risk of age-related diseases. Low Klotho levels are associated with a shorter lifespan and a higher risk of developing a range of conditions. Studies in mice demonstrated that those lacking Klotho aged prematurely and lived shorter lives. In humans, research indicates that lower Klotho levels are associated with an increased risk of developing age-related conditions.

Having a Higher Klotho Level May Reduce the Risk of:

• Cardiovascular Diseases: Klotho deficiency is a significant predictor of cardiovascular disease-related mortality and morbidity.
• Hypertension: Klotho plays a crucial role in modulating blood pressure through essential physiological processes.
• Alzheimer’s and Dementia: Research highlights Klotho’s potential to mitigate neurodegenerative processes, protecting brain health.
• Depression and Cognitive Impairment: Klotho’s role in mental and cognitive health is a key area of study, showing a positive connection.
• Cancer
• Kidney disease
• Diabetes
• Osteoporosis
• Autoimmune disorders

Conversely, individuals with higher Klotho levels often experience greater longevity and a longer healthspan—the number of years they live in good health.

The Anti-Aging Power of Klotho

Customized Klotho-based healthcare is poised to emerge as a powerful tool to fight back against the many ailments of aging. Klotho has been described as “the most potent anti-aging agent ever discovered.” Based on promising animal research, Klotho is seen as a potential “fountain of youth” for the future, with the ability to delay multiple aspects of aging simultaneously.

A growing body of data supports that managing your Klotho levels may contribute to reducing the risk of developing aging-related diseases, including cancer, hypertension, chronic inflammation, diabetes, calcification of arteries and heart valves, vision loss, memory loss, and more. Klotho may also play an essential role in managing addiction, depression, and suicide prevention. Klotho may contribute to gut microbiota health, which in turn supports immune system health and mood through proper serotonin release. Hair loss and skin wrinkles may also be prevented by managing Klotho levels.

Focusing on improving your Klotho level can complement a healthy lifestyle of diet, exercise, and stress reduction in optimizing your ability to remain healthy and active as you age.

The Two Forms of Klotho

Klotho exists in two primary forms in the body:

Membrane-bound Klotho: This form is attached to the surface of cells, especially in the kidneys. It works closely with a hormone called fibroblast growth factor 23 (FGF23), which is mainly produced in the bones. This partnership is crucial for regulating phosphate and vitamin D levels, both vital for strong bones and overall health.

Soluble Klotho (s-Klotho): This form circulates freely in the blood, urine, and cerebrospinal fluid (the fluid around the brain and spinal cord). It’s created when certain enzymes cut the membrane-bound form. Soluble Klotho acts like a hormone, delivering its beneficial effects to various organs and tissues throughout the body.

How Klotho Promotes Health

Klotho contributes to health and longevity in several significant and complex ways:

Mineral Balance: Especially in its membrane-bound form, Klotho helps control the levels of calcium, phosphate, and vitamin D in the blood. This is vital for strong bones and can help prevent issues like kidney stones

Blood Sugar Control: Klotho interacts with insulin receptors, improving how the body uses insulin. This helps manage blood sugar levels and can protect against diabetes

Cell Health: Klotho supports cell growth and helps cells survive by activating beneficial signaling pathways and preventing harmful ones

Protection from Damage: With its antioxidant and anti-inflammatory properties, Klotho helps protect cells from damage. It can boost protective enzymes and reduce inflammation

Inhibiting Aging Pathways: Notably, Klotho has been shown to slow down key pathways linked to aging, such as TGF-β, IGF-1, Wnt, and NF-κB. These pathways can lead to cellular aging, programmed cell death, inflammation, and tissue scarring. By regulating these, Klotho helps maintain healthy cells and tissues

Research and Therapeutic Potential

Researchers are actively exploring ways to increase Klotho levels as a potential treatment for many age-related diseases. Some strategies under investigation include:

Gene Therapy: Delivering genes that tell the cells to produce more Klotho protein. Studies in mice have shown that increasing soluble Klotho through gene therapy can extend lifespan and improve physical and cognitive health

Direct Protein Administration: Giving Klotho protein directly as a medication. The challenge here is to deliver it to the correct organs efficiently

Pharmacological Approaches: Identifying compounds that can naturally stimulate Klotho production or mimic its effects. For example, some studies suggest that exercise, certain medications (like ACE inhibitors, statins, and some antidiabetic drugs), and even certain supplements can influence Klotho levels

What is the KlothoYears Test?

An alpha Klotho (A-Klotho) human soluble Elisa based kit comprised of a solid phase sandwich for the determination of human soluble alpha Klotho in circulating blood. This level is compared to the average normal level for your age and is reported as a KlothoYears number.

Test Your Klotho Level

Understand your Klotho level and how it compares to others of your age and sex. Knowing your level can help you make informed decisions to boost your healthspan and longevity.

The KlothoYears team has selected Jinfiniti USA with more than 7 years experience for klotho blood test processing.

FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. Our Klotho Assay is a research-grade tool designed to measure soluble alpha-Klotho protein levels in serum or plasma. Klotho has been the subject of research exploring its potential role in various physiological processes, including those related to aging and longevity. This test is not intended to diagnose, treat, or cure any disease. By participating, you contribute to a growing dataset that may aid future scientific inquiry.

When you purchase our kit, you provide a biological sample. In our lab, we analyze this sample using a validated research protocol to determine your soluble alpha-Klotho protein concentration. We provide you with a quantitative result for informational purposes. This result has no established clinical significance and should not be used for any medical decision-making.

All clinics and customers ordering these Research Use Only Klotho Tests must agree to complete this research form or must confirm they are part of another IRB approved klotho related study (note this link form is just a sample look example the actual real research form will be in a HIPPA compliant database password protected).

At-Home Klotho Longevity Hormone Test AgingSOS® – Klotho Test

While we wait to finish validation of other testing labs we hereby refer you to order.

Quick, Easy, and Virtually Painless

Your Test kit includes Everything You Need to Collect Your Sample and send it to the Lab.

How the Process Works:

1. Place Your Order Online: Order your test kit online; it ships to your home or office.
2. Use a virtually-painless device to collect a capillary blood sample from your upper arm.
3. Label and pack your sample and test form in the shipping envelope.
4. Ship your sample to the lab via FedEx.
5. Receive your klotho test results by Email.

With the push of a button, draw a small blood sample from your upper arm in less than 5 minutes. Pack your sample and frozen gel pack in the shipping envelope, apply the prepaid label, and take it to FedEx for shipment to the lab.

Your Klotho Test Kit Includes

Everything you need for easy sample collection and return:

Self-Draw Blood Collection Device: This innovative device uses a gentle vacuum and microneedle technology for a virtually painless, easy collection from your upper arm capillaries.

Collection Supplies: Instructions, alcohol prep wipe, warming pad, collection tube, and a band-aid.

KlothoYears Sample Form: Important! Please complete this form with your information and include it with your sample to avoid delays.

Shipping Materials: A shipping envelope, plastic bag for your sample tube, a refrigerant gel pack (freeze before use!), and a prepaid FedEx 2-day air shipping label are included.

Shipping Your Sample to the Lab

• When to Collect & Ship: Samples must be drawn on a Monday, Tuesday, or Wednesday and shipped on the same day they are drawn to assure your sample arrives in good condition. Samples that arrive are warm, clotted or more than two days after they were drawn may need to be redrawn at extra cost.
• FedEx Drop-Off: A prepaid FedEx 2-Day Standard label is included. You are responsible for dropping off your sample at a FedEx location before their daily cut-off time, which is usually 4:30 pm; however, this may be earlier in remote areas. Find the cut-off time in your area on the FedEx website.
• Sample Collection Instructions

Understanding Klotho Levels

• Reference Ranges: The reference ranges we provide for Klotho levels are based on a study of 348 people that was the first to establish a reference range for soluble alpha-klotho in a wide age range of healthy adults (18-85). The study, using the IBL America α-Klotho ELISA test, confirmed that klotho levels naturally decline with age, a predictable result of the aging process. While there isn’t a single, universally accepted “normal” range for Klotho at present, other studies have found similar results. As more studies are conducted, reference ranges will be updated.
• Cutoff Value of Serum α-Klotho for Predicting All-Cause Mortality Risk: In the National Health and Nutrition Examination Study (NHANES) that included 13,746 U.S. adults with a survey-weighted mean age of 56.19 ± 10.42 years old, the optimal cutoff value of serum α-klotho for predicting all-cause mortality risk in the general population was 603.5 pg/ml. Individuals with low serum α-klotho (<603.5 pg/ml) had a significantly higher risk of all-cause and cardiovascular mortality.