Huntington Beach, California — April 23, 2026 — Lionheart Health today announced strong clinical outcomes from its OrthoStim™ bioelectric therapy program for knee osteoarthritis, alongside the launch of a next-generation, multi-modality Joint Health Treatment Protocol designed to restore function, reduce pain, and improve long-term joint resilience.
Clinical Results: OrthoStim™ Bioelectric Therapy
In multi-site observational clinical use and structured treatment programs, OrthoStim™ demonstrated meaningful improvements in pain, mobility, and functional performance among individuals with knee osteoarthritis.
Key Outcomes:
- Pain Reduction: 40%–65% improvement in patient-reported pain reduction scores
- Mobility Gains: Significant improvements in range of motion and joint flexibility
- Functional Improvement: Enhanced walking ability and daily activity performance plus improvement of gait speed
- Rapid Response: Many patients experienced noticeable improvement within the first 4–6 weeks
The OrthoStim™ protocol utilizes targeted bioelectric signaling (microcurrent + EMS) to attempt to:
- Enhance local circulation
- Modulate inflammation and reduce pain
- Activate endogenous repair pathways
- Stimulate regenerative protein expression (including Klotho and growth factors)
- Increase local klotho levels.
- Rebuild muscle.
- Strengthen bone.
“These results reinforce that bioelectric stimulation is not just symptomatic relief—it is a biological control system capable of activating the body’s own repair mechanisms,” said leadership at Lionheart Health. INVESTIGATIONAL.
Introducing the Lionheart Joint Health Treatment Protocol
Building on OrthoStim™ alone, Lionheart Health has developed a comprehensive, stacked regenerative protocol that combines in-clinic and at-home therapies for progressive joint restoration.
Core Components
1. Bioelectric OrthoStim™ Therapy (Foundation)
- Pulsed microcurrent + EMS targeting joint tissues
- Drives regenerative signaling and improved circulation
2. Bioelectric-Enhanced Biologics
- Platelet-rich fibrin (PRF)
- Peptides (targeted regenerative signaling)
- Stromal fraction derived from adipose tissue
- Designed to amplify repair and tissue regeneration
3. Adjunct Energy-Based Therapies
- Red light photobiomodulation
- Pulsed electromagnetic field therapy (PEMF)
- Electrical muscle stimulation (EMS)
4. Regenerative Support Serums
- Topical and injectable formulations supporting extracellular matrix repair
5. Whole-Body Optimization
- BodStim™ bioelectric suit exercise platform
- Enhances systemic Klotho expression, muscle strength, and metabolic support
6. Advanced OUS Regenerative Option (Select Clinics Only)
- Klotho-expressing stem cells suspended in nutrient hydrogel
- Designed to further amplify regenerative signaling within the joint environment
Hybrid Delivery Model: Clinic + At-Home
The protocol is designed as a longitudinal care model, combining:
- In-clinic intensive treatment sessions
- At-home continuation therapies (including BodStim™ and adjunct devices)
This hybrid structure enables:
- Continuous regenerative signaling
- Higher patient compliance
- Scalable global deployment
A New Category: Regenerative Bioelectric Joint Care
Unlike traditional approaches focused on symptom management (pain medications, injections, or surgery), Lionheart’s protocol represents a paradigm shift toward functional restoration.
Differentiation:
- Non-invasive + minimally invasive continuum
- Multi-pathway activation (bioelectric + biologics + metabolic)
- Designed for scalability across clinics and home use
- Targets underlying biology—not just symptoms
Addressing a Global Need
Knee osteoarthritis affects hundreds of millions of people worldwide, often leading to chronic pain, reduced mobility, and eventual joint replacement surgery.
Lionheart Health’s approach aims to:
- Delay or avoid surgical intervention
- Improve quality of life
- Extend functional healthspan
Availability
The Joint Health Treatment Protocol is now being introduced across:
- Lionheart licensed clinics
- Specialty partner clinics (sports medicine, regenerative medicine, and longevity centers)
Advanced biologic components, including stem cell therapies, are currently offered only outside the United States (OUS) at select partner clinics in accordance with local regulations.
About Lionheart Health
Lionheart Health is a leader in bioelectric regenerative medicine, developing technologies that activate the body’s natural repair systems through targeted electrical signaling. The company’s platform focuses on improving muscle, brain, vascular, and regenerative function, with applications across aging, chronic disease, and performance optimization.
Forward-Looking Statements and Disclaimer
Contact
Lionheart Health