Overview
The Lionheart Bone Density Improvement Protocol™ is our most advanced bone-strength and skeletal resilience program, created for people who want more than standard bone health advice. This premium protocol combines targeted bioelectric stimulation with the Lionheart Stimulus 240, BodStim™ enhanced exercise, advanced recovery therapies, and precision regenerative support to help create a stronger, healthier bone-building environment.
At Lionheart, we believe bone health is not just about slowing decline. It is about helping your body rebuild strength, improve structural support, enhance circulation, activate muscle, and support the regenerative signals associated with healthier aging.
What Makes This Program Different
Most bone health programs focus on a few basics. Lionheart goes further with a multi-modality strategy designed to support the full biologic environment around bone.
Your customized program may include:
- Lionheart Stimulus 240 bioelectric stimulation — targeted programs designed to support bone-building and repair-associated signaling
- BodStim™ enhanced exercise — helps add muscle activation, loading support, and stronger musculoskeletal conditioning
- Osteogenic loading-style training — brief, supervised high-force loading techniques designed to help support healthy skeletal adaptation
- PEMF and advanced electromagnetic therapies — used to support tissue conditioning, recovery, and musculoskeletal performance
- Photobiomodulation red light therapy — added to support cellular energy, recovery, and regenerative signaling
- Hyperbaric oxygen therapy — helps support oxygen delivery and healing biology in select programs
- Sauna, cold plunge, and recovery therapies — used to support resilience, circulation, recovery, and performance
- Vibration therapy and KlothoPod II chamber elements — integrated in select programs to support whole-body conditioning, balance, and healthy aging optimization
Powered by Lionheart’s Regenerative Bioelectric Science
This protocol is built around Lionheart patents issued and pending focused on bioelectric support of regenerative protein expressions associated with bone strength, structure, circulation, and tissue quality, including:
BMP9, OPG, klotho, COL17A1, sirtuins, sestrins, apelin, tropoelastin, eNOS, VEGF, SDF1, PDGF, S100A, and CXCL5
These signaling targets are part of Lionheart’s broader vision to help support:
- Stronger bone biology
- Better remodeling balance
- Healthier circulation
- Connective tissue quality
- Stem cell recruitment support
- Improved musculoskeletal aging
Nutrition and Supplement Coaching Included
True bone optimization requires more than devices alone. That is why this protocol also includes coaching for:
- Bone-supportive nutrition
- Protein optimization
- Calcium and vitamin D support
- Magnesium and vitamin K support
- Strength-building lifestyle habits
- Posture and balance training
Advanced Regenerative Support Options
For those seeking a more advanced program, Lionheart may also integrate:
- Bioelectric peptides
- Bioelectric-enhanced PRF
- Bioelectric-enhanced exosomes and secretomes
- Stromal fraction from adipose tissue via SynovaWave™
- Umbilical cord or Muse cell infusions or injections
- Klotho gene therapy
Advanced biologic and gene-based offerings are available only outside the United States through licensed partner clinics where permitted.
Who This Is For
This protocol is ideal for those who want to:
- Support bone density and skeletal strength
- Improve posture, balance, and confidence in movement
- Support stronger muscles alongside stronger bones
- Pursue a more advanced healthy aging strategy
- Access a premium, multi-modality bone optimization experience
The Lionheart Vision
We are not interested in basic bone care. We are building the future of bone regeneration support, skeletal resilience, and stronger aging from the inside out.
Lionheart Bone Density Improvement Protocol™ is designed for people who want a bold, comprehensive, next-generation approach to supporting stronger bones, stronger movement, and a stronger future.
How Lionheart’s Bioelectric Bone Support Programs Are Designed to Work
Bone is living tissue. It is constantly remodeling in response to mechanical loading, circulation, inflammation, hormones, mineral balance, and regenerative signaling. Lionheart’s bone-support programs are designed to use targeted bioelectric stimulation plus weight-bearing and muscle-loading exercise to help create a more favorable environment for bone maintenance and repair. This is based on the broader biology that bone cells respond to electrical and mechanical cues, and that bone remodeling is governed by signaling pathways that influence both osteoblasts (bone-building cells) and osteoclasts (bone-resorbing cells).
Key Regenerative Signaling Targets
BMP-9 — BMP-9 is one of the strongest known osteogenic growth factors in preclinical research. It helps push stem and progenitor cells toward an osteoblast fate, increases osteogenic differentiation, and supports mineralized bone formation. In simple terms: it may help tell the body, “build more bone.” Preclinical and translational studies report strong osteoinductive potential for BMP-9.
OPG (osteoprotegerin) — OPG acts like a protective brake on bone breakdown. It binds RANKL and helps prevent excessive activation of osteoclasts, the cells that dissolve bone. In simple terms: more OPG support may help shift bone remodeling away from breakdown and toward preservation or rebuilding.
Klotho — Klotho is associated with healthy aging, mineral regulation, calcium-phosphate balance, and skeletal homeostasis. It appears to influence the bone environment both directly and indirectly through systemic metabolism and aging biology. In simple terms: klotho may help make the whole bone environment more youthful and better regulated. Klotho’s bone role is promising, but complex and still being actively studied.
Sirtuins — Sirtuins are cellular “maintenance” proteins involved in energy sensing, mitochondrial health, inflammation control, and tissue repair. In bone, they are linked to better osteoblast function and lower osteoclast-driven resorption, partly through pathways such as RUNX2, AMPK, Wnt/β-catenin, mTOR, and NF-κB. In simple terms: they may help bone cells perform more like repair cells and less like stressed aging cells. Most evidence remains preclinical.
Sestrins — Sestrins are stress-response proteins tied to oxidative stress control, autophagy, AMPK signaling, and metabolic resilience. They are relevant because bone-building cells are sensitive to inflammation and oxidative damage. In simple terms: sestrin-supportive signaling may help protect the repair environment bone needs. This is a mechanistic inference from stress-response and regeneration biology and is more investigational than OPG or BMP-9.
PDGF — PDGF is a classic repair and recruitment signal. It can help attract progenitor cells, support blood vessel growth, and accelerate early tissue repair responses. In bone, PDGF may be most helpful in the early healing and vascular support phase, but its effects can depend on timing and context; some studies show it can also interfere with BMP-driven bone formation in certain settings. In simple terms: PDGF may help call in repair resources, but it has to be balanced properly.
SDF-1 / CXCL12 — SDF-1 is a major stem cell homing signal. It helps recruit mesenchymal stem cells and other progenitor cells into injured or remodeling tissues. In simple terms: SDF-1 may help bring the body’s own repair cells to where they are needed. Its role in bone and cartilage metabolism is increasingly recognized, especially in regeneration models.
Apelin — Apelin is a signaling peptide tied to vascular function, metabolism, inflammation control, and musculoskeletal health. Preclinical studies suggest it may support osteoblast activity and protect bone-supportive cells under stress, though some studies also show more complex effects on osteoclast biology. In simple terms: apelin may help support a healthier bone-and-blood-supply environment, but it is still a developing target rather than an established clinical bone-density lever.
COL17A1 — COL17A1 is better known for its role in epithelial stem-cell anchoring and tissue regenerative integrity than as a mainstream bone-density target. Lionheart’s interest here is more about regenerative matrix quality and tissue resilience than a direct, proven bone-mineral-density effect. In simple terms: COL17A1 may matter for how well tissues maintain regenerative capacity, but its direct role in bone density is currently much less established than BMP-9 or OPG.
LIM-related signaling — LIM-domain proteins are involved in mechanosensing, cytoskeletal organization, and muscle-bone force transfer. This matters because bone responds to force, and muscle-generated loading is one of the strongest natural signals for bone adaptation. In simple terms: better mechanotransduction may help turn exercise and loading into stronger bone-building signals. This is a broader mechanobiology concept rather than a single validated consumer-facing bone biomarker claim.
Why Combine Bioelectric Stimulation with BodStim™ and Weight-Bearing Exercise?
Lionheart combines signaling programs with BodStim™ enhanced exercise and weight-bearing training because bone responds best when biology and mechanics work together. Exercise provides the load signal; circulation and recovery therapies may support the repair environment; and regenerative signaling targets are intended to support the cellular instructions for remodeling. Established bone-health guidance strongly supports weight-bearing and resistance exercise, while many of the molecular-target claims above remain investigational, preclinical, or translational rather than proven as standalone clinical bone-density treatments.
Pricing
Your first clinic session is $588, which includes your initial assessment, treatment setup, and first Lionheart Stimulus™ 240 session. Each clinic session thereafter is $288.
- BodStim™ Suit Lease — BodStim™ suits are available to lease for $890 down and $188 per month, allowing you to complete enhanced exercise sessions at home between clinic visits.
- Bone Health Supplements — Recommended bone-supportive supplements typically range from $2 to $9 per day, depending on your personalized plan.
Summary
Lionheart’s bioelectric bone programs are designed to support stronger bones by influencing both sides of the bone equation: helping encourage bone-building signals such as BMP-9 and stem-cell recruitment pathways such as SDF-1, while also supporting anti-breakdown pathways such as OPG, healthy-aging pathways such as klotho and sirtuins, and the circulation, matrix, and recovery environment bone needs to remodel well. Some of these targets are well grounded in bone biology, while others are promising next-generation regenerative targets still under active study.
How it works: Lionheart Bone Density Improvement Protocol™ is designed to combine bioelectric signaling, BodStim™ enhanced exercise, and weight-bearing loading to support the biology of bone remodeling. Our programs focus on signaling targets associated with bone formation (BMP-9), reduced bone breakdown (OPG), stem-cell homing (SDF-1), healthy aging and mineral regulation (klotho), cellular repair metabolism (sirtuins and sestrins), vascular and repair support (PDGF and apelin), and tissue matrix quality (including investigational targets such as COL17A1 and LIM-related mechanosensing pathways). Together, these programs are intended to help create a stronger bone-building environment.
For Clinicians and Nurses
Clinician Use Framework
Core Program Schedule
- Lionheart Stimulus™ 240 Stimulator sessions: 2 times per week
- Duration per Stimulus 240 session: 60 minutes
- BodStim™ enhanced exercise sessions: 3 times per week
- Duration per BodStim session: 60 minutes
- BodStim sessions may be performed in clinic, at home, or in a hybrid clinic/home model
- Weight-bearing exercise training should be incorporated into the BodStim™ exercise program
Program Goal
Support a healthier bone-building environment through a combined program of:
- Targeted bioelectric stimulation
- BodStim™ enhanced exercise
- Weight-bearing and resistance-focused activity
- Posture, balance, and musculoskeletal conditioning
- Nutrition and supplement coaching
- Selected adjunctive recovery and regenerative-support therapies as appropriate
Recommended Initial Treatment Course
Initial intensive phase: 12 weeks. During this period patients complete:
- 2 Lionheart Stimulus™ 240 sessions weekly
- 3 BodStim™ enhanced exercise sessions weekly
Program may then transition to a personalized maintenance phase based on response, tolerance, adherence, physician assessment, bone density goals, and balance, strength, and posture progress.
Lionheart Stimulus™ 240 Session Structure
Each 60-minute clinic session may include:
- Patient check-in and symptom review
- Positioning and treatment preparation
- Targeted bioelectric stimulation using bone-supportive treatment programs
- Optional addition of selected supportive modalities where indicated
- Session completion, reassessment, and follow-up instructions
BodStim™ Enhanced Exercise Structure
Each 60-minute BodStim™ session may include:
- Warm-up
- BodStim™ muscle activation exercise
- Weight-bearing exercise
- Resistance exercise
- Posture and balance work
- Cool-down and recovery
- Home adherence tracking when performed outside clinic
Weight-Bearing Exercise Component
The BodStim™ bone support exercise plan should emphasize:
- Standing weight-bearing movements
- Resistance-based lower body training
- Core strengthening
- Posture support work
- Balance and fall-risk reduction exercises
- Progressive loading as tolerated and medically appropriate
Delivery Model
- Clinic-based model: all sessions completed under supervision
- Hybrid model: Lionheart Stimulus™ 240 in clinic, BodStim™ in clinic and at home
- Home-supported model: clinic-directed program with remote adherence support for BodStim™ exercise sessions
Adjunctive Optional Add-Ons
As clinically appropriate, the protocol may also include:
- PEMF
- High-intensity electromagnetic therapies
- Radiofrequency-based support modalities
- Photobiomodulation / red light therapy
- Vibration therapy
- Sauna
- Cold plunge or other cold therapies
- Hyperbaric oxygen
- Additional KlothoPod II chamber supportive modalities
Advanced Regenerative-Support Options
In selected programs, Lionheart may also integrate:
- Bioelectric peptides
- Bioelectric-enhanced PRF
- Stromal fraction from adipose tissue via SynovaWave™
- Exosomes and secretomes
- Umbilical cord or Muse cell infusions or injections
- Klotho gene therapy
Advanced biologic and gene-based therapies are available only outside the United States through licensed OUS clinics where permitted.
Clinician Summary
Lionheart Bone Density Improvement Protocol™ combines Lionheart Stimulus™ 240 bioelectric stimulation sessions 2 times per week for 1 hour with BodStim™ enhanced exercise sessions 3 times per week for 1 hour, performed in clinic or at home, together with weight-bearing exercise, strength training, posture and balance work, nutrition coaching, and selected recovery and regenerative-support therapies to help support a stronger bone-building environment.