Overview
The Lionheart Joint Health Protocol is a physician-guided, investigational program designed to reduce knee pain and inflammation, stimulate endogenous cartilage repair, and restore long-term joint function through advanced bioelectric protein expression therapy. Powered by Klotho activation and regenerative signaling, this comprehensive approach targets the root causes of joint degeneration by elevating key proteins including Klotho, IGF-1, SDF-1, Follistatin, VEGF, and BMP-7/9. Combined with bioelectric-enhanced PRF injections, red light therapy, PEMF, muscle strengthening, and personalized supplements, this protocol helps you move freely, reduce pain, and support lasting joint health. Contact us to inquire about qualifying for an active clinical study.
Key Benefits
This regenerative protocol delivers comprehensive joint restoration:
- Reduces knee pain and inflammation
- Increases joint lubrication and cartilage quality
- Stimulates stem cell homing and endogenous repair
- Improves muscle strength, stability, and alignment
- Enhances local circulation, synovial fluid flow, and mitochondrial health
How It Works
The Joint Health Protocol is structured as 80–90 minute sessions performed twice weekly for 6–12 weeks, with each session combining multiple regenerative modalities for maximum effect.
Intake and Baseline Testing
Your first visit includes comprehensive assessment with knee pain VAS score, KOOS (Knee Injury & Osteoarthritis Outcome Score), range of motion and gait assessment, quad and hamstring EMG activation testing, and optional ultrasound imaging of joint space to establish baseline measurements and track progress.
Bioelectric Knee Regeneration Session
This 25–30 minute treatment uses the Lionheart Bioelectric Stimulator to activate protein expressions for cartilage regeneration, reduce inflammation, attract stem cells, and elevate Klotho. The bioelectric signal sequence targets specific proteins with precise frequencies: Klotho upregulation (20 Hz microcurrent with alternating polarity) for anti-inflammatory and antioxidant effects that slow cartilage degeneration, SDF-1 stem cell homing (10–20 Hz) to draw circulating MSCs to the knee, IGF-1 expression (40–80 Hz) for cartilage regeneration and chondrocyte proliferation, BMP-7 and BMP-9 (72–90 Hz) for joint cartilage and bone strength formation, Follistatin boost (250–350 Hz) to reduce myostatin and support muscle and tendon healing, VEGF (15–25 Hz) for improved microcirculation, IL-10 expression (3–5 Hz) for anti-inflammatory effects, and TNF-α inhibition through counter-signal pulsing to reduce inflammatory cytokines. Each signal runs for approximately 3 minutes with pads placed medial, lateral, and posterior to the knee using comfortable, sub-sensory low-intensity microcurrent.
Bioelectric-Enhanced PRF Injection
Performed once weekly, this optional but recommended treatment draws patient blood, spins it for Platelet-Rich Fibrin (PRF), places the PRF tube on a microcurrent plate (Lionheart PRF Enhancer) with Klotho, IGF-1, VEGF, SDF-1, and Follistatin signals for 6 minutes, then injects the enhanced PRF into the affected knee (intra-articular and peri-tendon if needed). This process enhances growth factor potency, improves stem cell recruitment, and increases anti-inflammatory and repair signals inside the joint.
Red Light and PEMF Synergy
This 15-minute treatment combines red light therapy (630–660 nm and 810–850 nm) applied for 10–12 minutes to the entire knee capsule and quadriceps insertion to increase mitochondrial ATP, reduce inflammation, and improve tissue repair. PEMF therapy follows with 5–10 minutes of low-frequency field (10–30 Gauss) to improve circulation, reduce swelling, and enhance nutrient transfer.
EMS Muscle Toning for Joint Stability
A 10–12 minute session using quad, hamstring, and glute EMS pads at 25–35 Hz strengthening frequency focuses on VMO activation for proper knee tracking. This improves strength of the supporting musculature critical for joint stability and proper biomechanics.
Anti-Inflammatory Ointment Application
A 3-minute therapeutic application uses Klotho-supporting peptides (Lionheart formula), Arnica or Boswellia, Magnesium MSM cream, and Curcumin transdermal preparations. The technique involves 2 minutes of circular motion over the joint line and 1 minute over the quad tendon area for maximum absorption.
BodStim™ EMS Klotho and Follistatin Boosting Exercise
This 10-minute session is performed after passive therapies for maximal uptake. While wearing the BodStim knee and quad configuration, you’ll perform assisted mini-squats, step-ups, resistance band leg press, terminal knee extensions (TKEs), and optional slow reverse treadmill walking. The bioelectric EMS signal uses Klotho-boosting patterns, Follistatin/myostatin-reducing patterns, and 20–40 Hz blended EMS for strength, resulting in improved neuromuscular activation, better stability, superior joint loading mechanics, and maximized signaling for repair.
Home-Care Regimen
Daily support includes an optional bioelectric home unit for 20-minute nightly knee microcurrent with Klotho, SDF-1, and IGF-1 programs. The supplement protocol includes Klotho peptides, Collagen II with Hyaluronic Acid, Omega-3 (2–4g), Curcumin (500–1000 mg), Vitamin D3 with K2, and Lionheart Longevity “Inflam-Shield” blend. Lifestyle modifications include daily 20-minute light walking, avoiding deep compressive loading early in treatment, and optional nightly contrast therapy.
What to Expect
The protocol duration is typically 6 weeks for mild to moderate joint pain and 12 weeks for osteoarthritis stages II–III, with monthly maintenance sessions thereafter. Most participants experience reduced knee pain within 2–3 sessions, inflammation reduction within 1 week, range of motion improvements in 2–4 weeks, and weekly muscle activation improvements. The synergy of PRF and bioelectric therapy creates visible functional improvement within 6–12 weeks, with long-term structural improvement achieved through sustained Klotho elevation and stem cell homing signals.
Ideal For
This protocol is ideal for individuals experiencing knee pain, osteoarthritis, cartilage degeneration, reduced mobility, joint inflammation, or post-injury joint dysfunction. It’s also well-suited for those seeking a proactive, regenerative approach to joint health and longevity rather than relying solely on pain management or surgical intervention.