Bioelectric stimulation plus repeat infusions of a mixed composition of biologics for treating severe depression. In early stages of development. Biologics mix may include any of stem cells, selected growth factors, selected alkaloids such as tetraharmine, exosomes, secretome from amniotic sourcing, stromal fraction from adipose tissue, micro RNA gel, nutrient hydrogel, oxygenated nanoparticles, Wharton’s jelly, bioelectric pre-treated PRF and matrix. Stem cells may include hypoxia treated and klotho expressing MSCs. Stimulation electrodes may include impregnated gel with therapeutic serums added.