ImplantStim™

The Technology: How it Works

The ImplantStim™ technology is based on pioneering patents and patent pending:

• Patented bioelectric signaling sequence for controlling OPG expression for osseointegration.
• Patent pending bioelectric sequence for controlling KLOTHO expression.
• Patented bioelectric signaling sequence for controlling RANKL expression.
• Patent pending bioelectric sequence for controlling IGF1 expression.
• Patented combination of bioelectics and biologics for accelerated healing.
• Patent pending bioelectric PRF combination.

Also included is a patented method wherein the bioelectric stimulation device causes OPG release to enhance osteoblast formation and bone formation/re-mineralization for tooth stability.

Product Development Pipeline

The ImplantStim engineering team is developing three products:

• ImplantStim™: Bioelectric stimulation controlled protein expressions for accelerated healing.
• ImplantStim™ Wireless: Wireless electromagnetic energy controlled protein expressions for accelerator healing.
• ImplantStim™ Plus: Bioelectric stimulation + IS-15 proprietary biologics composition for accelerated healing including patent pending Bioelectric PRF™ and regenerative fluid derived from amniotic fluid and exosomes.

ImplanStim Plus is our 2nd generation product development which combines bioelectrics with biologics, such as platelet rich fibrin for even more rapid healing and for treating the most severe cases.

Target Goals of the ImplantStim Therapy

• 70% Improvement of bone formation (osteogenesis)
• 400% Acceleration of the healing process via osteointegration by controlled bioelectric release of OPG and other healing promoting proteins.
• 70% Reduction of pain an discomfort
• 50% Increase in bone to implant (BIC)
• 70% Increase in trabecular bone volume density
• Reduce the need for repeat/repair surgeries

Clinical Impact & Patient Suitability

The ImplantStim™ controlled bioelectric protein expressions technology is designed to actively stimulate, accelerate and improve osteogenesis (bone formation) by 70% and is intended to accelerate osseointegration (bone to implant connection) by up to 400%. Even proven successful in clinical studies, this will shorten the healing time by 2/3rds after implant placement as well as enabling the loading of the implant (crown placement) after only 1/3 of the usual time.

The ImplantStim™ technology may be a suitable alternative for patients who may not normally be considered good candidates for implants with poor bone quality from underlying diabetes or other autoimmune disorders as well as heavy smokers and drinkers.

System Specifications

A system to selectively administer electrical stimuli to a patient, comprising: a programmable source of variable frequency, variable amplitude electrical signals, whereby the frequency is capable of being varied within a range of approximately 0.1 to 970 hertz and the amplitude is capable of being varied within a range of approximately 20 to 400 microamps; and a plurality of electrodes to connect the source to a patient, whereby the variable frequency, variable amplitude electrical signals are applied as electrical stimuli to a region proximate to the mouth of the patient to perform a predetermined protocol.