HUNTINGTON BEACH, Calif. — May 9, 2026 — Lionheart Health, Inc. today announced the launch of its new Multi-Modality Bone Density Improvement Protocol Study through its longevity and regenerative medicine platform, Lionheart Longevity.
Protocol brief description is here > https://lionheartlongevity.com/treatment/bone-density-improvement-protocol/
The study is designed to evaluate the combined effects of bioelectric stimulation, targeted exercise, PEMF, red light therapy, nutrition, peptide support, and regenerative biologics on bone density, bone strength, mobility, recovery, and healthy aging.
The Lionheart Bone Density Improvement Protocol uniquely incorporates proprietary bioelectric signaling programs designed to support the expression and activation of regenerative proteins associated with bone formation and skeletal resilience, including:
- BMP9 (Bone Morphogenetic Protein 9)
- OPG (Osteoprotegerin)
- Klotho
Lionheart Health has developed pioneering patent portfolios related to bioelectric stimulation directed toward regenerative protein expression, including technologies intended to support bone regeneration, stem cell homing, tissue repair, vascular support, and healthy aging pathways.
BMP9 is increasingly recognized as one of the most osteogenic bone morphogenetic proteins involved in bone formation and skeletal remodeling. OPG plays a critical role in helping regulate bone resorption and protecting against excessive osteoclast activity. Klotho has emerged as one of the most important longevity-associated proteins connected to bone metabolism, mineral balance, kidney health, inflammation modulation, and musculoskeletal aging.
Published scientific literature has demonstrated strong mechanistic relationships between Klotho signaling and preservation of bone integrity and mineral density. Additional research has linked BMP signaling and OPG regulation to osteoblast differentiation, bone remodeling, and fracture healing.
According to Lionheart Health Executive Chairman & Co-CEO Howard J. Leonhardt:
“Most bone density programs focus on only one intervention. Our approach is fundamentally different. We are combining bioelectric protein expression technologies with exercise, regenerative medicine, nutrition, circulation enhancement, muscle strengthening, inflammation reduction, and healthy aging optimization in one integrated protocol designed to help the body regenerate and preserve skeletal resilience.”
The protocol combines multiple modalities including:
- Lionheart 240 Stimulus™ bioelectric stimulation systems
- BodStim™ muscle preservation and strengthening programs
- PEMF therapy
- Red light photobiomodulation
- Bioelectric enhanced peptides
- Nutritional optimization
- Weight-bearing exercise and resistance training
- Optional PRF and regenerative biologics support
- Klotho optimization strategies
The company believes the protocol may have applications for:
- Age-related bone density decline
- Recovery support after orthopedic injury
- Frailty prevention
- Executive and athletic longevity programs
- Healthy aging and mobility optimization
- Muscle and skeletal resilience under stress
Lionheart Health’s broader platform focuses on bioelectric stimulation technologies designed to support regenerative protein expression throughout the body, including applications in joint health, muscle performance, cognition, skin regeneration, hair restoration, sexual health, and healthy aging optimization.
The company is also participating in the XPRIZE Healthspan competition as a top 40 semi-finalist and previously received the AbbVie Allergan ULP Innovation Award for innovation in regenerative aesthetics and bioelectric protein expression technologies.
Mechanism paragraph
The Lionheart Bone Density Improvement Protocol is based on the concept that bone regeneration is optimized when mechanical loading, muscle contraction, cellular bioelectric signaling, mitochondrial activation, vascular support, and osteoblast/osteoclast balance are addressed together. Bioelectric stimulation and EMS may support bone through muscle-driven mechanical strain, improved circulation, osteogenic signaling, and modulation of inflammatory pathways. PEMF has published support for bone healing and remodeling through effects on RANKL/OPG, Wnt/β-catenin, calcium signaling, extracellular matrix production, and osteoblast activity. Photobiomodulation may enhance mitochondrial ATP production, reduce oxidative stress, support angiogenesis, and promote osteoblast proliferation and differentiation. At the molecular level, BMP9 is one of the strongest osteogenic BMPs for driving mesenchymal stem cell differentiation toward bone-forming osteoblasts; OPG helps protect bone by acting as a decoy receptor against RANKL-mediated osteoclast activation; Klotho is linked to mineral metabolism, kidney-bone signaling, inflammation modulation, and lower osteoporosis risk; sirtuins and sestrins connect exercise, mitochondrial health, oxidative-stress control, AMPK/mTOR signaling, and skeletal aging; and follistatin/follistatin-like pathways connect muscle hypertrophy, exercise adaptation, activin regulation, and bone remodeling. Together, these mechanisms support a multi-modality study design aimed at improving bone density, muscle strength, balance, joint resilience, and healthy aging markers.
Selected references
- Electrical stimulation / bioelectric signaling: Farjaminejad S. The role of electrical stimulation in bone regeneration. 2025.
- Electrical stimulation and osteoporosis: Zhang W. The Possible Role of Electrical Stimulation in Osteoporosis. 2023.
- EMS / NMES and bone loading: Abitante TJ. Potential of Neuromuscular Electrical Stimulation as a Mechanotherapy for Bone. 2022.
- Whole-body EMS and osteopenia: von Stengel S. Whole-Body Electromyostimulation to Fight Osteopenia in Elderly Women. 2015.
- PEMF osteogenesis: Varani K. Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis. 2021.
- PEMF bone healing: Caliogna L. Pulsed Electromagnetic Fields in Bone Healing. 2021.
- Photobiomodulation and bone repair: Lu P. The role of photobiomodulation in accelerating bone repair. 2024.
- Photobiomodulation and bone defects: Vigliar MFR. Photobiomodulation Therapy Improves Repair of Bone Defects. 2024.
- BMP9 osteogenesis: Park JH. BMP-9 Improves Osteogenic Differentiation Ability. 2023.
- BMP9 review: Bharadwaz A. Osteogenic Differentiation Cues of BMP-9. 2021.
- OPG/RANKL bone balance: Kostenuik PJ. Osteoprotegerin and RANKL regulate bone resorption, density and strength. 2005.
- OPG/RANK/RANKL pathway: Trouvin AP. Maintaining the Balance to Prevent Bone Loss. 2010.
- Klotho and osteoporosis risk: Jiang J. Klotho reduces the risk of osteoporosis in postmenopausal women. 2023.
- Osteocyte Klotho and bone metabolism: Komaba H. Klotho expression in osteocytes regulates bone metabolism. 2017.
- Sirtuins and bone biology: Li Q. Role of sirtuins in bone biology. 2021.
- SIRT1 and osteoporosis: Chen Y. Sirt1: An Increasingly Interesting Molecule with a Potential Role in Osteoporosis. 2024.
- Sestrins and exercise benefits: Kim M. Sestrins are evolutionarily conserved mediators of exercise benefits. 2020.
- Sestrins, metabolism and aging: Lee JH. Sestrins orchestrate cellular metabolism to attenuate aging. 2013.
- Follistatin-like proteins and exercise-driven bone formation: Nam J. Follistatin-like 3 is a mediator of exercise-driven bone formation. 2015.
- Follistatin and BMD association: Jürimäe J. Follistatin is associated with bone mineral density
Investigational research stage.
For additional information visit:
Lionheart Longevity Bone Density Protocol
Forward Looking Statements
This press release contains forward-looking statements regarding investigational technologies, regenerative medicine concepts, bioelectric signaling platforms, and potential wellness applications. These technologies are under ongoing development and evaluation and are not intended to diagnose, treat, cure, or prevent disease unless specifically cleared or approved by regulatory authorities.