New option combines longevity practices associated with Japan’s centenarian population with Lionheart’s personalized Klotho-Up™ program
HUNTINGTON BEACH, Calif., September 21, 2026 — Lionheart Longevity today announced the Japan Centenarian Protocol™, a new optional pathway within its healthspan longevity membership program.
The protocol combines nutrition, daily movement, muscle preservation, preventive healthcare, restorative sleep, social connection and purposeful living—principles associated with Japan’s exceptional longevity—with Lionheart’s clinician-guided Klotho-Up™ Protocol.
“Japan’s centenarian population demonstrates that extraordinary longevity is rarely attributable to one treatment or supplement,” said Howard J. Leonhardt, Executive Chairman and Co-CEO of Lionheart Health, Inc. “It reflects a lifetime of healthy nutrition, consistent movement, strong relationships, preventive care and meaningful purpose. Our Japan Centenarian Protocol builds upon those lessons with personalized testing, muscle-strengthening technology and our Klotho-Up program.”
The Japan Centenarian Membership Pathway
Depending on individual needs and clinical guidance, the pathway may include:
- Comprehensive baseline health and biological-aging assessment
- Klotho and inflammation biomarker testing
- Japanese-inspired nutrition emphasizing vegetables, fish, soy, seaweed, mushrooms, fermented foods and portion awareness
- Daily walking, mobility and natural movement
- Resistance training and BodStim™ EMS sessions two to three times weekly
- Personalized Klotho-Up™ nutritional and lifestyle support
- Sleep optimization and stress-management practices
- Social engagement, continuing education and purposeful activity
- Optional clinician-directed photobiomodulation, PEMF or hyperbaric oxygen support
- Progress reassessment at approximately 12 weeks and comprehensive annual testing
“Our objective is not simply to help people live longer, but to help them preserve strength, cognition, independence and engagement throughout those additional years,” said Dr. Leslie Miller, Chief Medical Officer of Lionheart Health. “The program emphasizes measurable healthspan outcomes and individualized adjustments based on each member’s response.”
Members may select the Japan Centenarian Protocol™ as their primary Lionheart Longevity pathway or incorporate appropriate components into an existing Klotho-Up™ membership plan.
The Lionheart Longevity Formula
Eat wisely. Move daily. Preserve muscle. Support resilience. Stay connected. Live with purpose. Measure progress.
For membership information and participating locations, visit LionheartLongevity.com.
About Lionheart Health
Lionheart Health is developing and commercializing a portfolio of bioelectric, regenerative-health and healthspan-longevity technologies. Its programs are designed to support muscle health, circulation, cognitive performance, tissue repair and healthy aging through personalized assessments, lifestyle interventions and clinician-guided technologies.
Important Notice: The Japan Centenarian Protocol™ is inspired by longevity-associated lifestyle practices and does not imply that Japanese centenarians used Lionheart products or treatments. Individual results vary. Certain Klotho-directed, peptide, cellular, gene-based or combination interventions may be investigational and available only through appropriately authorized research protocols with medical oversight and informed consent. No Lionheart membership program is intended to replace individualized medical diagnosis or treatment.
Media Contact:
Lionheart Health, Inc.
www.LionheartLongevity.com
THE JAPAN CENTENARIAN PROTOCOL™
Japanese Longevity Lessons + the Lionheart Klotho-Up™ Protocol
A physician-guided program inspired by the nutrition, movement, social connection and preventive-health practices associated with Japanese longevity—enhanced by Lionheart Health’s personalized Klotho-Up™ approach.
- Measure Your Biological Baseline
Assess Klotho, biological-age biomarkers, inflammation, metabolic health, cognition, muscle strength, body composition, cardiovascular fitness and microbiome health. - Follow a Japanese-Inspired Diet
Emphasize vegetables, fish, soy, seaweed, fermented foods, mushrooms, green tea and minimally processed foods. Practice portion control—eat slowly and stop before feeling completely full. - Move Naturally Every Day
Walk, stretch, garden, climb stairs and remain physically engaged throughout the day. Minimize prolonged sitting. - Build and Preserve Muscle
Complete resistance exercise two to three times weekly, supported when appropriate by the BodStim™ Klotho-Expressing EMS Suit to augment the healthspan benefits of exercise. - Activate the Klotho-Up™ Program
Under professional supervision, incorporate the individualized Lionheart Klotho-Up™ program, potentially including BodStim™, targeted bioelectric stimulation, Rejuvant® AKG, SNIP™, KlothaMax™ and clinician-selected nutritional support. - Protect Sleep and Recovery
Maintain a consistent sleep schedule, obtain morning daylight, reduce evening stimulation and address sleep apnea or other sleep disorders. - Strengthen Purpose and Social Connection
Cultivate ikigai—a continuing sense of purpose. Maintain close relationships, group activities, family engagement, learning and meaningful service. - Manage Stress and Inflammation
Practice breathing exercises, meditation, time in nature and other daily recovery rituals. Optional physician-directed support may include photobiomodulation, PEMF or hyperbaric oxygen therapy. - Prevent Problems Early
Maintain regular medical examinations, dental care, vaccinations and screening for cardiovascular disease, cancer, diabetes, cognitive decline and loss of muscle or bone. - Reassess and Personalize
Repeat key biomarkers and functional testing after approximately 12 weeks, with a comprehensive reassessment at 12 months. Adjust the program according to measured response.
The Lionheart Formula
Eat wisely. Move daily. Preserve muscle. Raise resilience. Stay connected. Live with purpose. Measure progress.
The Japan Centenarian Protocol™ is inspired by observed longevity-associated practices and does not imply that Japanese centenarians used Lionheart products. Certain Klotho-directed, peptide, cellular, gene-based or combination interventions may be investigational and available only through appropriately authorized research protocols with informed consent and medical oversight. This program is not intended to diagnose, treat, cure or prevent disease.
References:
1. Baseline health and biological-aging assessment
Supports measuring conventional health risks, physical function, cognition, frailty and selected aging biomarkers.
- Moqri M, et al. “Biomarkers of aging for the identification and evaluation of longevity interventions.” Cell, 2023. PubMed PMID 37657418
- Fried LP, et al. “Frailty in older adults: evidence for a phenotype.” Journal of Gerontology: Medical Sciences, 2001. Established weakness, walking speed, activity, exhaustion and weight loss as meaningful frailty measures. PubMed PMID 11253156
- Bhasin S, et al. “Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium.” Journal of the American Geriatrics Society, 2020. Supports grip strength, gait speed and mobility testing. PubMed PMID 32150289
Evidence note: Biological-age tests are useful research and tracking tools, but no single commercial biological-age test is yet accepted as a definitive surrogate for longer life.
2. Klotho and inflammation measurements
- Chuang MH, et al. “Association between soluble α-Klotho and mortality risk in middle-aged and older adults.” Frontiers in Endocrinology, 2023. Observational evidence linking circulating Klotho with mortality risk. PubMed PMID 37693344
- Xu Y, Sun Z. “Molecular basis of Klotho: from gene to function in aging.” Endocrine Reviews, 2015. Reviews Klotho biology involving oxidative stress, mineral metabolism and age-associated pathways. PubMed search
Evidence note: Soluble Klotho remains an exploratory biomarker. Assay methods, reference ranges and within-person variation must be controlled. It should not be presented as a stand-alone diagnostic of biological age.
3. Japanese-inspired dietary pattern
- Kurotani K, et al. “Quality of diet and mortality among Japanese men and women: Japan Public Health Center-based prospective study.” BMJ, 2016. Greater adherence to Japanese dietary guidelines was associated with lower mortality. PubMed PMID 27005903
- Katagiri R, et al. “Association of soy and fermented soy product intake with total and cause-specific mortality.” BMJ, 2020. Large Japanese prospective cohort; fermented-soy intake was associated with lower mortality, although causation was not established. PubMed PMID 31996350
- Kuriyama S, et al. “Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan.” JAMA, 2006. Prospective Japanese cohort evidence supporting an association between green-tea consumption and reduced mortality, particularly cardiovascular mortality. PubMed PMID 16968850
- Kraus WE, et al. “Two years of calorie restriction and cardiometabolic risk.” The Lancet Diabetes & Endocrinology, 2019. CALERIE randomized trial supporting moderate calorie reduction in non-obese adults. PubMed PMID 31303390
Evidence note: The evidence supports an overall dietary pattern—not claims that one food causes longevity. “Stop before completely full” should be presented as a portion-awareness practice, not a clinically proven treatment.
4. Daily walking and natural movement
- Paluch AE, et al. “Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts.” The Lancet Public Health, 2022. Higher daily step counts were associated with progressively lower mortality, with benefits occurring below 10,000 steps per day. PubMed PMID 35247352
Protocol implication: Set an individualized step and mobility goal based on baseline function rather than requiring the same number for every member.
5. Resistance exercise and muscle preservation
- Momma H, et al. “Muscle-strengthening activities are associated with lower risk and mortality in major non-communicable diseases.” British Journal of Sports Medicine, 2022. Systematic review and meta-analysis supporting regular muscle-strengthening activity. PubMed PMID 35228201
- Fried LP, et al. Frailty phenotype study, cited above. Supports monitoring weakness, physical activity and walking performance. PubMed PMID 11253156
6. Whole-body EMS and BodStim™
- Kemmler W, et al. “Whole-body electromyostimulation and protein supplementation favorably affect sarcopenic obesity in community-dwelling older men at risk: the randomized controlled FranSO study.” Clinical Interventions in Aging, 2017. PubMed PMID 28989278
- Kemmler W, et al. Follow-up analysis of whole-body EMS and cardiometabolic risk in older men with sarcopenic obesity. BMC Geriatrics, 2018. PubMed PMID 29523089
Evidence note: These studies support whole-body EMS as a muscle-conditioning intervention in selected populations. They do not independently establish that BodStim™ increases Klotho or extends lifespan. Any BodStim-specific Klotho claim should cite Lionheart’s IRB protocol, assay laboratory, sample size and results separately.
7. Klotho-Up™ nutrition and supplements
- Demidenko O, et al. “Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8-year reduction in biological aging … in the TruAge DNA methylation test.” Aging, 2021. PubMed PMID 34847066
- Gaitán JM, et al. “Physical exercise improves memory in sedentary middle-aged adults: Are these benefits associated with soluble Klotho?” FIT-AGEING randomized trial, 2023. PubMed PMID 37823465
Evidence limitations:
- The Rejuvant study was not a randomized, placebo-controlled longevity trial and used a biological-age estimate rather than disease or survival outcomes.
- Exercise-related changes in Klotho do not establish that Klotho itself caused the observed benefit.
- Independent peer-reviewed human outcome studies should be supplied before making specific efficacy claims for SNIP™, KlothaMax™ or the combined Klotho-Up™ formulation.
- These products should currently be described as clinician-selected nutritional support—not proven anti-aging treatments.
8. Sleep regularity and recovery
- Windred DP, et al. “Sleep regularity is a stronger predictor of mortality risk than sleep duration: a prospective cohort study.” Sleep, 2024. PubMed PMID 37738616
Protocol implication: Track bedtime and wake-time consistency, sleep duration, sleep quality and possible sleep apnea. Screening and referral are stronger claims than promising that sleep optimization will extend life.
9. Purpose, learning and social connection
- Alimujiang A, et al. “Association between life purpose and mortality among US adults older than 50 years.” JAMA Network Open, 2019. PubMed PMID 31125099
- Boyle PA, et al. “Purpose in life is associated with mortality among community-dwelling older persons.” Psychosomatic Medicine, 2009. PubMed PMID 19414613
- Holt-Lunstad J, et al. “Social relationships and mortality risk: a meta-analytic review.” PLOS Medicine, 2010. PubMed PMID 20668659
Evidence note: These are strong associations, but they do not establish that ikigai alone causes longer life.
10. Stress-management practices
- Creswell JD, et al. “Mindfulness-Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults.” Brain, Behavior, and Immunity, 2012. Randomized trial. PubMed PMID 22708533
Protocol implication: Breathing, meditation and nature exposure can be presented as stress-management and well-being practices. Broad claims of systemic inflammation reversal should be avoided.
11. Preventive examinations and screening
- U.S. Preventive Services Task Force. Current evidence-based recommendations for cardiovascular risk, cancer, diabetes, osteoporosis, depression and other preventive services. USPSTF recommendations
- Centers for Disease Control and Prevention. Evidence-based adult immunization schedule. CDC adult vaccination schedule
Protocol implication: Screening should follow age, sex, medical history and risk factors—not a uniform package for every member.
12. Photobiomodulation
- de Oliveira BH, et al. “Transcranial photobiomodulation increases cognition and serum BDNF levels in adults over 50 years: a randomized, double-blind, placebo-controlled trial.” Journal of Photochemistry and Photobiology B, 2024. PubMed PMID 39423445
Evidence note: This supports further investigation for specific cognitive outcomes. It does not establish lifespan extension or general rejuvenation.
13. Pulsed electromagnetic field therapy
- Yang X, et al. “Effects of pulsed electromagnetic field therapy on pain, stiffness, physical function, and quality of life in patients with osteoarthritis.” Systematic review and meta-analysis of randomized placebo-controlled trials, 2020. PubMed PMID 32251502
Evidence note: PEMF evidence is principally condition-specific, such as osteoarthritis symptoms. It should not be marketed as a generally proven longevity treatment.
14. Hyperbaric oxygen therapy
- Hachmo Y, et al. “Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial.” Aging, 2020. PubMed PMID 33206062
Evidence note: This was a relatively small prospective study without a conventional placebo-control design. Changes in blood-cell telomeres are not proof of rejuvenation, disease prevention or increased lifespan. HBOT also has contraindications and should remain an optional physician-directed service.
15. Twelve-week and annual reassessment
No single study establishes 12 weeks as the universal optimal interval for a longevity program. It is a reasonable operational checkpoint for adherence, safety, strength, body composition and selected biomarkers. Annual reassessment should align with conventional clinical guidelines and the member’s risk profile.