OrthoStim is a bioelectronic medicine company focused on joint and tissue regeneration. Using patented bioelectric signaling and advanced biologics, it aims to restore mobility, reduce inflammation, and eliminate chronic pain without surgery.
Discover our background, mission, and the world-class research driving our next-generation medical technology.
To eliminate chronic joint pain and disability through advanced bioelectronic medicine. OrthoStim is designed to harness the body’s natural healing potential using precision-controlled protein expressions to manage inflammation, promote regeneration, and restore mobility without invasive surgery.
OrthoStim is an American regenerative medicine company (labs in Utah and California) focused on bioelectric stimulation and mixed stem cell-based technologies. Based on pioneering research initiated in the 1980s by the Leonhardt team, we provide new approaches to the regeneration of bone, muscle, tendon, and cartilage.
Want to learn more? Browse our clinical resources and scientific publications on our latest updates and insights.
The Lionheart Stimulus™ 240 Stimulator is a professional-grade 4-channel electrotherapy…
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Discover the science and innovation driving our advanced solutions, designed to deliver safe, effective, and transformative results.
Imagine if you could eliminate the pain of joint arthritis with simple bioelectric stimulations. OrthoStim™ is an American regenerative medicine company (with labs and operations in Utah and California) dedicated to providing innovative bioelectric and mixed stem cell-based composition treatments for people suffering from arthritis, tendon, muscle, bone, cartilage, and soft tissue injuries, diseases, and conditions.
Imagine if you could harness your body’s own healing potential so that you could regenerate your own joints instead of having a major surgery with artificial implants. Our technology is designed to add bioelectric controlled protein expressions for inflammation management, healing, pain relief, and regeneration promotion to your favorite brand knee braces.
Based on tissue and organ regeneration work that began in the 1980s by the Leonhardt team, OrthoStim™ develops bioelectric stimulation-based therapies that activate the homing of progenitor cells within the body to target stimulated tissues and restore health. Progenitor cells are the natural sources of tissues throughout your body and remain present through adulthood.
Bioelectronic medicine uses small micro-implanted or benchtop stimulation devices to deliver targeted electrical pulses directly to target tissue, muscle, cartilage, tendon, or bone. It is designed to provide “built-in” therapy at a lower cost and improved safety compared to standalone drug or biologic options.
OrthoStim™ is the first and only patented bioelectric knee and joint stimulator that controls with precision regenerative protein expressions. The platform includes the InStim™ technology for real-time reading and bioelectric signal modulation and management of inflammation. Our signals are programmed for:
For very severe advanced cases, we combine bioelectric stimulation with repeat deliveries of our proprietary OS-15 fifteen-component regeneration composition via a re-fillable micro-infusion pump. This includes:
ePulse™ Conductive Knee Wrap & Stimulator
Utilizes TENS electro-pulses to block pain signals from the nerves traveling through the knee region to the brain to provide temporary relief.
The latest accessory designed to apply TENS pulses to nerve clusters throughout the elbow to block pain signals sent to the brain.
Our technology is designed for the following target areas:
Indications:
Knee, Hip, Elbow, Tendon, Cartilage, Bone, and Muscle.
Primary Goals:
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Our primary therapeutic treatment for joint recovery is reading the inflammation of the joint via bioelectric signal and cytokine sensing and then custom designing a bioelectric stimulation sequence to deliver a patient specific customized solution. Within our bioelectric reader and stimulator micro-processors are stored healing sequences previously recorded from ideal optimal healing recoveries that serve as a baseline. We have 19 patented or patent pending precise bioelectric signals that control expression of specific proteins for specific purposes. These include SDF-1 for stem cell homing. IGF-1 for DNA repair. Tropoelastin for increasing elasticity. VEGF, PDGF, HIF1a, eNOS and SDF-1 for increasing blood supply and circulation. BMP 9 and OPG for bone formation when needed. Follistatin for new muscle formation when required. A full array of IL and other anti-inflammatory cytokines. We also have bioelectric signals that help control the differentiation of recruited or injected stem cells into useful target tissues, tendon, bone or cartilage. Our bioelectric therapy is usually provided via two platforms – (1) a high fidelity high precision bench top bioelectric stimulator in clinic with two 20 to 40 minute treatment sessions a week for about 8 to 12 weeks and (2) a portable mobile stimulator taken home that is worn within a conductive wrap that is placed over the joint. This mobile stimulation is applied whenever that patient feels comfortable to do so until full recovery is affected. The late Dr. Y. King Liu, one of our longstanding advisors, invented and patented a knee/joint wrap that is precision set up to deliver bioelectric signals along the proven acupuncture pathways derived from thousands of years of practice of eastern acupuncture medicine. For severe recovery cases we combine our bioelectric regeneration therapy with a re-fillabable micro infusion pump that is refilled daily, weekly or monthly with our OS-15 fifteen component joint regeneration and recovery composition comprised of stem cells, growth factors, amniotic fluid, platelet rich fibrin, BMP-9, exosomes, selected micro RNAs, selected alkaloids, engineered nutrient hydrogel and joint specific matrix.
1. Bioelectric InStim inflammation treatment 2X a week for 40 minutes each for 3 weeks prior to stem cell injections. Reads inflammation and real time adjusts bioelectric signals to control anti-inflammatory cytokines release on demand.
2. Bioelectric stem cell recruiting and protein expression treatment in clinic for regeneration 2X a week for 20 to 40 minutes for 16 weeks. Includes SDF-1, IGF-1, HGF, EGF, PDGF, VEGF, HIF1a, eNOS, Activin, Follistatin, Tropoelastin, BMPs.
3. Adipose or bone marrow derived stem cell injections with may be suspended (where regulatory agencies accept) in a growth factor cocktail, amniotic fluid, PRF, nutrient hydrogel, selected exosomes, micro RNAs, selected alkaloids and joint matrix- 1X a month for 6 months or until joint is recovered.
4. PRP, PRF, Amniotic Fluid injections – 1X per month for 6 months or until joint is recovered.
5. @ home stimulation with portable microcurrent leg, knee, calf and foot electric stimulation microcurrent garments (joint wrap) – use everyday until recovery.
6. Electro-acupuncture with Dr. Y. King Liu patented knee brace wrap one treatment day a month for 6 to 18 months or until joint is recovered.
Treatment protocol will vary depending on regulatory constraints in certain countries and physician preference.
Want to learn more? Browse our clinical resources and scientific publications on our comprehensive suite of targeted treatments.
Strategic guidelines and executive summaries focused on clinical study management and venture goals.
Scientific evidence exploring how electrical currents improve physical function and manage chronic pain.
Research regarding Klotho protein expression and its critical role in anti-aging and long-term joint health.
Advanced studies on regenerative biologics, mesenchymal stem cells, and exosome-based joint tissue repair.
Analysis of molecular signaling pathways and targeted proteins used for bone and cartilage regeneration.
Exploration of platelet-rich fibrin and engineering scaffolds used to optimize native tissue repair.
Want to learn more? Browse our clinical resources and scientific publications on our latest updates and insights.
CAUTION Disclaimer and Warning:
Products described on this web site are in early stage development and are not yet proven safe or effective in statistically significant controlled clinical studies. Any statement or phrases implying efficacy or safety in any form are considered modified by “intended to” or “designed to”. Investigational use only in countries where investigation is permitted by law and proper filings have been made and appropriate regulatory clearances have been granted. Any use of the product(s) must be in an authorized clinical study with institutional review board (ethics committee) approval and proper patient consent procedures followed. For other countries product is only available for laboratory investigation by credentialed institutions and investigators with proper clearances with a research agreement in place with a study sponsor. NOT AVAILABLE FOR SALE.
Whether you are a patient seeking non-invasive pain relief or a clinician looking for standardized protocols, OrthoStim provides the framework for the future of orthopedic care.
